Vitamin D3 & K2 Nutramedix capsules

Delivery time: 1-3 working days within Germany, 5-10 days within Europe
Regular price €29,95 EUR
Sale price €29,95 EUR Regular price

Vitamin D is an essential vitamin that is involved in numerous vital body functions. It helps maintain bone health and strengthens the immune system.

1 capsule contains: Vitamin D3 (cholecalciferol) 125 yg = 5000 IU (corresponding to 625% of the recommended daily dose) Vitamin K2 (Menaquenine-7) 150 yg (corresponding to 125% of the recommended daily dose) Other ingredients: microcrystalline cellulose, vegetarian capsule shell, di-calcium phosphate, magnesium stearate from plant sources

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Why Vitamin D3 & K2 Nutramedix capsules

Vitamin D - the sunshine vitamin for the immune system, bones and muscles.

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Further information

Vitamin D is avital vitamin,which is involved in numerous body functions. So it plays a crucial role for thatimmune systemas well as theBone, muscle and dental health.In contrast to most other vitamins, it is hardly present in food, but up to 90% is synthesized through the skin through exposure to sunlight. However, UV radiation in Germany is too weak to synthesize sufficient vitamin D. Experts therefore suspect thatAround 60% of the German population suffers from a vitamin D deficiencyand recommend an additional supplement, especially in winter. Vitamin K2 supports the positive effects, so that the two vitamins complement each other and strengthen each other's effects.

You have further questions?

We try to answer all your questions with the best of our conscience. If you have any further questions, you can contact us at any time.

Can you premix NutraMedix drops?

All drop preparations can be mixed together in the same glass of water. The mixture can be stored in the refrigerator for several days before consumption.

How many drops are in a bottle?

Each 30 ml bottle of our liquid products contains around 600 drops, correspondingly each 60 ml bottle contains around 1200 drops and each 120 ml bottle contains around 2400 drops. This way you can easily calculate how many days a product will last.

How high is our bioavailability?

When we say that our products have high bioavailability, we mean that all of our products are designed to be easily absorbed by the body at a cellular level. That's why we offer many of our products in liquid form.

My child takes NutraMedix products. Is the dosage different?

The recommended dose of NutraMedix products is intended for an average-sized adult weighing 60 - 85 kg. For children, a guideline value of 1/4 of the specified dose per 15 kg of body weight may apply.

Are there scientific studies and sources on the ingredients?

The sources listed serve to provide information regarding the ingredients of this product. They do not claim to be complete or exclusive.

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2 Institute of Medicine. (2011). Dietary Reference Intakes for Calcium and Vitamin D. Washington, DC: The National Academies Press.

3 Binkley, N., Ramamurthy, R., & Krueger, D. (2010). Low vitamin D status: definition, prevalence, consequences, and correction. Endocrinology and metabolism clinics of North America, 39(2), 287–contents.

4 Martineau, AR, Thummel, KE, Wang, Z., Jolliffe, DA, Boucher, BJ, Griffin, SJ, Forouhi, NG, & Hitman, GA (2019). Differential Effects of Oral Boluses of Vitamin D2 vs Vitamin D3 on Vitamin D Metabolism: A Randomized Controlled Trial. The Journal

of clinical endocrinology and metabolism, 104(12), 5831–5839.

5 Booth SL (2012). Vitamin K: food composition and dietary intakes. Food & nutrition research, 56, 10.3402/fnr.v56i0.5505.

6 Institute of Medicine. (2001). Panel on Micronutrients. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington (DC): National Academies

Press (U.S.). Available from: https://www.ncbi.nlm.nih.gov/books/NBK222310/

7 Sherf-Dagan, S., Goldenshluger, A., Azran, C., Sakran, N., Sinai, T., & Ben-Porat, T. (2019). Vitamin K – what is known regarding bariatric surgery patients: a systematic review. Surgery for Obesity and Related Diseases, 15(8) , 1402-1413.

8 Shearer, MJ, Bach, A., & Kohlmeier, M. (1996). Chemistry, nutritional sources, tissue distribution and metabolism of vitamin K with special reference to bone health. The Journal of nutrition, 126(4 Suppl), 1181S–6S.

9 Office of Dietary Supplements. (2021). Office of Dietary Supplements - Vitamin K. Ods.od.nih.gov. Retrieved August 18, 2021, from https://ods.od.nih.gov/factsheets/vitaminK-HealthProfessional/.

10 Halder, M., Petsophonsakul, P., Akbulut, AC, Pavlic, A., Bohan, F., Anderson, E., Maresz, K., Kramann, R., & Schurgers, L. (2019). Vitamin K: Double Bonds beyond Coagulation Insights into Differences between Vitamin K1 and K2 in Health and Disease.

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11 Schurgers, LJ, Teunissen, KJ, Hamulyák, K., Knapen, MH, Vik, H., & Vermeer, C. (2007). Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. Blood, 109(8), 3279–3283.

12 van Ballegooijen, AJ, Pilz, S., Tomaschitz, A., Grübler, MR, & Verheyen, N. (2017). The Synergistic Interplay between Vitamins D and K for Bone and Cardiovascular Health: A Narrative Review. International journal of endocrinology, 2017, 7454376.

13 Prietl, B., fahrer, G., Pieber, TR, & Amrein, K. (2013). Vitamin D and immune function. Nutrients, 5(7), 2502-2521.

14 Siddiqui, M., Manansala, JS, Abdulrahman, HA, Nasrallah, GK, Smatti, MK, Younes, N., Althani, AA, & Yassine, HM (2020). Immune Modulatory Effects of Vitamin D on Viral Infections. Nutrients, 12(9), 2879.

15 Szymczak, I., & Pawliczak, R. (2016). The Active Metabolite of Vitamin D3 as a Potential Immunomodulator. Scandinavian journal of immunology, 83(2), 83–91.

16 Mpandzou, G., Aït Ben Haddou, E., Regragui, W., Benomar, A., & Yahyaoui, M. (2016). Vitamin D deficiency and its role in neurological conditions: A review. Revue neurologique, 172(2), 109–122.

17 Iijima, H., Shinzaki, S., & Takehara, T. (2012). The importance of vitamins D and K for the bone health and immune function in inflammatory bowel disease. Current opinion in clinical nutrition and metabolic care, 15(6), 635–640.

18 Jung, HC, Seo, MW, Lee, S., Kim, SW, & Song, JK (2018). Vitamin D₃ Supplementation Reduces the Symptoms of Upper Respiratory Tract Infection during Winter Training in Vitamin D-Insufficient Taekwondo Athletes: A Randomized Controlled Trial.

International journal of environmental research and public health, 15(9), 2003.

19 Martineau, AR, Jolliffe, DA, Hooper, RL, Greenberg, L., Aloia, JF, Bergman, P., Dubnov-Raz, G., Esposito, S., Ganmaa, D., Ginde, AA, Goodall, EC, Grant, CC, Griffiths, CJ, Janssens, W., Laaksi, I., Manaseki-Holland, S., Mauger, D., Murdoch, DR, Neale,

R., Rees, JR, … Camargo, CA, Jr (2017). Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ (Clinical research ed.), 356, i6583.

20 Judd, SE, & Tangpricha, V. (2009). Vitamin D deficiency and risk for cardiovascular disease. The American journal of the medical sciences, 338(1), 40-44.

21 Podzolkov, VI, Pokrovskaya, AE, & Panasenko, OI (2018). Vitamin D deficiency and cardiovascular pathology. Terapevticheskii arkhiv, 90(9), 144–150.

22 Giménez, V., Sanz, RL, Marón, F., Ferder, L., & Manucha, W. (2020). Vitamin D-RAAS Connection: An Integrative Standpoint into Cardiovascular and Neuroinflammatory Disorders. Current protein & peptide science, 21(10), 948–954.

23 El Asmar, MS, Naoum, JJ, & Arbid, EJ (2014). Vitamin k dependent proteins and the role of vitamin k2 in the modulation of vascular calcification: a review. Oman medical journal, 29(3), 172-177.

24 Charoenngam, N., & Holick, M.F. (2020). Immunologic Effects of Vitamin D on Human Health and Disease. Nutrients, 12(7), 2097.

25 Khundmiri, SJ, Murray, RD, & Lederer, E. (2016). PTH and Vitamin D. Comprehensive Physiology, 6(2), 561–601.

26 Kodama, Y., Okamoto, Y., Kubota, T., Hiroyama, Y., Fukami, H., Matsushita, K., & Kawano, Y. (2017). Effectiveness of vitamin K2 on osteoporosis in adults with cerebral palsy. Brain & development, 39(10), 846-850.

27 Zoch, ML, Clemens, TL, & Riddle, RC (2016). New insights into the biology of osteocalcin. Bone, 82, 42-49.

28 Wen, L., Chen, J., Duan, L., & Li, S. (2018). Vitamin K dependent proteins involved in bone and cardiovascular health (Review). Molecular medicine reports, 18(1), 3–15.

29 Mocanu, V., Stitt, PA, Costan, AR, Voroniuc, O., Zbranca, E., Luca, V., & Vieth, R. (2009). Long-term effects of giving nursing home residents bread fortified with 125 microg (5000 IU) vitamin D(3) per daily serving. The American journal of clinical nutrition,

89(4), 1132-1137.

30 Myneni, V.D., & Mezey, E. (2018). Immunomodulatory effect of vitamin K2: Implications for bone health. Oral diseases, 24(1-2), 67-71.

31 Yasui, T., Miyatani, Y., Tomita, J., Yamada, M., Uemura, H., Miura, M., & Irahara, M. (2006). Effect of vitamin K2 treatment on carboxylation of osteocalcin in early postmenopausal women. Gynecological endocrinology: the official journal of the International

Society of Gynecological Endocrinology, 22(8), 455–459.

32 Iwamoto, J., Takeda, T., & Ichimura, S. (2003). Treatment with vitamin D3 and/or vitamin K2 for postmenopausal osteoporosis. The Keio journal of medicine, 52(3), 147-150.

33 Moretti, R., Morelli, ME, & Caruso, P. (2018). Vitamin D in Neurological Diseases: A Rationale for a Pathogenic Impact. International journal of molecular sciences, 19(8), 2245.

34 Di Somma, C., Scarano, E., Barrea, L., Zhukouskaya, VV, Savastano, S., Mele, C., Scacchi, M., Aimaretti, G., Colao, A., & Marzullo, P . (2017). Vitamin D and Neurological Diseases: An Endocrine View. International journal of molecular sciences, 18(11), 2482.

35 Boontanrart, M., Hall, SD, Spanier, JA, Hayes, CE, & Olson, JK (2016). Vitamin D3 ages microglia immune activation by an IL-10 dependent SOC3 mechanism. Journal of Neuroimmunology, 292(2016), 126-136.

36 Jia, J., Hu, J., Huo, X., Miao, R., Zhang, Y., & Ma, F. (2019). Effects of vitamin D supplementation on cognitive function and blood Aβ-related biomarkers in older adults with Alzheimer's disease: a randomized, double-blind, placebo-controlled trial. journal

of neurology, neurosurgery, and psychiatry, 90(12), 1347–1352.

37 Alisi, L., Cao, R., De Angelis, C., Cafolla, A., Caramia, F., Cartocci, G., Librando, A., & Fiorelli, M. (2019). The Relationships Between Vitamin K and Cognition: A Review of Current Evidence. Frontiers in neurology, 10, 239.

38 Bhargava, P., Fitzgerald, KC, Calabresi, PA, & Mowry, EM (2017). Metabolic alterations in multiple sclerosis and the impact of vitamin D supplementation. JCI insight, 2(19), e95302.

39 Han, Q., Li, X., Tan, Q., Shao, J., & Yi, M. (2019). Effects of vitamin D3 supplementation on serum 25(OH)D concentration and strength in athletes: a systematic review and meta-analysis of randomized controlled trials. Journal of the International Society

of Sports Nutrition, 16(1), 55.

40 Koutkia, P., Chen, TC, & Holick, MF (2001). Vitamin D intoxication associated with an over-the-counter supplement. The New England journal of medicine, 345(1), 66-67.

41 Carlton, S., Clopton, D., & Cappuzzo, K.A. (2010). Vitamin D deficiency: appropriate replenishment therapies and the effects of vitamin D toxicity. The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists, 25(3), 171–177.

42 Letavernier, E., & Daudon, M. (2018). Vitamin D, Hypercalciuria and Kidney Stones. Nutrients, 10(3), 366.

43 Demontis, R., Leflon, A., Fournier, A., Tahiri, Y., Herve, M., Moriniere, P., Abdull-Massih, Z., Atik, H., Belbrik, S., & Renaud , H. (1986). 1 alpha(OH) vitamin D3 increases plasma aluminum in hemodialized patients taking AI(OH)3. Clinical nephrology, 26(3), 146–149.

44 Schwartz JB (2009). Effects of vitamin D supplementation in atorvastatin-treated patients: a new drug interaction with an unexpected consequence. Clinical pharmacology and therapeutics, 85(2), 198–203.

45 Escribano, J., Balaguer, A., Pagone, F., Feliu, A., & Roqué I Figuls, M. (2009). Pharmacological interventions for preventing complications in idiopathic hypercalciuria. The Cochrane database of systematic reviews, 2009(1), CD004754.

46 Bar-Or, D., & Gasiel, Y. (1981). Calcium and calciferol antagonize effect of verapamil in atrial fibrillation. British medical journal (Clinical research ed.), 282(6276), 1585–1586.

47 Natural Medicines. (2021, August 19). Vitamin K [monograph]. http://naturalmedicines.therapeuticresearch.com

48 Crowther MA, Ageno W, Garcia D, Wang L, Witt DM, Clark NP, Blostein MD, Kahn SR, Vesely SK, Schulman S, Kovacs MJ, Rodger , MA, Wells, P., Anderson, D., Ginsberg, J., Selby, R., Siragusa, S., Silingardi, M., Dowd, MB, & Kearon, C. (2009).

Oral vitamin K versus placebo to correct excessive anticoagulation in patients receiving warfarin: a randomized trial. Annals of internal medicine, 150(5), 293-300.

Important information about the product description (disclaimer)

This product and its description do not replace a visit to the doctor and do not represent a promise of healing, but rather serve to provide information. The statements made are based on traditional traditions and experience and have not been proven by scientific studies. If you have serious or unclear symptoms, please seek medical advice.